Feini (Sylvia) Qu, VMD, PhD
Assistant Professor
Biography
Dr. Feini (Sylvia) Qu is an Assistant Professor of Orthopaedics & Sports Medicine and Mechanical Engineering and a core faculty member at the University of Washington's Institute for Stem Cell and Regenerative Medicine (ISCRM). Dr. Qu is the Allan Treuer-Ted Wagner, MD Endowed Chair in Regenerative Spine Surgery. Dr. Qu trained as a veterinarian-scientist at the University of Pennsylvania and was a postdoctoral fellow at Washington University in St. Louis prior to joining the University of Washington.
Her current goal is to understand the cellular and molecular pathways of composite musculoskeletal tissue regeneration, especially with respect to the bone and connective tissues of limbs and joints. Her research program uses the murine digit tip to identify pathways that regulate tissue morphogenesis after amputation and to test potential therapies, providing a translational framework to regenerate tissues or organs as complex as an entire limb.
Publications
Qu F, Palte IC, Gontarz PM, Zhang B, Guilak F. Transcriptomic analysis of bone and fibrous tissue morphogenesis during digit tip regeneration in the adult mouse. FASEB Journal. 2020 Jul; 34(7):9740-9754.
Qu F, Guilak F, Mauck RL. Cell Migration: Implications for Repair and Regeneration in Joint Disease. Nature Reviews Rheumatology. 2019 Jan; 15:167-179.
Qu F*, Holloway JL*, Esterhai JL, Burdick JA, Mauck RL. Programmed Biomolecule Delivery to Enable and Direct Cell Migration for Connective Tissue Repair. Nature Communications. 2017 Nov; 8(1):1780. *Co-first authors.
Qu F, Li Q, Wang X, Cao X, Zgonis MH, Esterhai JL, Shenoy VB, Han L, Mauck RL. Tissue Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues. Scientific Reports. 2018 Feb; 8(1):3295.
Qu F, Pintauro MP, Haughan JE, Henning EA, Esterhai JL, Schaer TP, Mauck RL, Fisher MB. Repair of Dense Connective Tissues via Biomaterial-Mediated Reprogramming of the Wound Interface. Biomaterials. 2015 January; 39:85-94.
Qu F, Lin JG, Esterhai JL, Fisher MB, Mauck RL. Biomaterial-Mediated Delivery of Degradative Enzymes to Improve Meniscus Integration and Repair. Acta Biomaterialia. 2013 May; 9(5):6393-402.
Qu F, Stoeckl BD, Gebhard PM, Hullfish TJ, Baxter JR, Mauck RL. A Wearable Magnet-Based System to Assess Activity and Joint Flexion in Humans and Large Animals. Ann Biomed Eng. 2018 Dec; 46(12):2069-2078.
Hullfish TJ, Qu F, Stoeckl BD, Gebhard PM, Mauck RL, Baxter JR. Measuring Clinically Relevant Knee Motion With A Self-Calibrated Wearable Sensor. J Biomech. 2019 May; 89:105-109.
Bansal S, Keah NM, Neuwirth A, O'Reilly O, Qu F, Seiber B, Mandalapu S, Mauck RL, Zgonis MH. Large Animal Models of Meniscus Repair and Regeneration: A Systematic Review of the State of the Field. Tissue Eng Part C Methods. 2017 Aug; 23(11):661-672.
Bansal S, Mandalapu S, Aeppli C, Qu F, Szczesny S, Mauck RL, Zgonis MH. Mechanical Function Near Defects in an Aligned Nanofiber Composite is Preserved by Inclusion of Disorganized Layers: Insight into Meniscus Structure and Function. Acta Biomaterialia. 2017 July; 45:102-109.
Li Q, Qu F, Han B, Wang C, Li H, Mauck RL, Han L. Micromechanical Anisotropy and Heterogeneity of the Meniscus Extracellular Matrix. Acta Biomaterialia. 2017 May; 54:356-366.
Li Q, Wang C, Han B, Qu F, Hao Q, Li CY, Mauck RL, Han L. Impacts of Maturation on the Micromechanics of the Meniscus Extracellular Matrix. J Biomech. 2018. April 2017; 72:252-257.
Riggin CN, Qu F, Kim DH, Huegel J, Steinberg DR, Soslowsky LJ, Mauck RL, Bernstein J. Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation. Ann Biomed Eng. 2017 Jun; 45(10):2348- 235.
Nwe K, Huang CH, Qu F, Warden-Rothman R, Mauck RL, Tsourkas A. Cationic Gadolinium Chelate for Magnetic Resonance Imaging of Cartilage Defects. Contrast Media Mol Imaging. 2016; 11(3): 229-235.
Koga T, Ji Y, Seo YS, Gordon C, Qu F, Rafailovich MH, Sokolov JC, Satija SK. Neutron Reflectivity Study of Glassy Polymer Brushes in Density Fluctuating Supercritical Carbon Dioxide. J Polymer Sci Part B. 2004; 42(17):3282-3289.
Book Chapters
Qu F, Fisher MB, Mauck RL. Basic Science of Meniscus Repair: Limitations and Emerging Strategies. Meniscal Injuries: Management and Surgical Techniques. Ed. J.D. Kelly, IV. Springer Science+Business Media, LLC, 2014. pp 105-114.
Patents
Qu F, Gebhard PM. Systems and Methods for Joint Activity Monitoring. US Patent 20170231533 A1. Filed Aug 21, 2015.